DNA-immunization with a V2 deleted HIV-1 envelope elicits protective antibodies in macaques.
Immunol Lett
; 79(1-2): 47-55, 2001 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-11595289
ABSTRACT
Rhesus macaques immunized with the HIV-1 SF162DeltaV2 gp140 envelope using the DNA-prime plus protein-boost vaccination methodology, developed HIV envelope-specific T-cell lymphoproliferative responses and potent neutralizing antibodies. To evaluate the protective potential of these antibodies during acute infection, the animals were depleted of their CD8+ T lymphocytes using specific monoclonal antibodies and subsequently challenged intravenously with the pathogenic SHIV(SF162P4) isolate. As compared to non-vaccinated animals (one of which died from AIDS 16 weeks post-exposure) the vaccinated macaques had lower levels of peak viremia, rapidly cleared virus from the periphery and developed delayed seroconversion to SIV core antigens.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anticuerpos Anti-VIH
/
Productos del Gen env
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VIH-1
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Vacunas contra el SIDA
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Vacunas de ADN
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Macaca mulatta
Límite:
Animals
Idioma:
En
Revista:
Immunol Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos