The effect of injection rate on time-resolved contrast-enhanced peripheral MRA.
J Magn Reson Imaging
; 14(4): 401-10, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11599064
ABSTRACT
In contrast-enhanced (CE) magnetic resonance (MR) angiography (MRA), lower injection rates of a fixed contrast agent dose provide longer contrast agent bolus at the expense of lower intravascular signal. This study evaluated the effect of different injection rates in imaging of the vasculature of the lower extremities with time-resolved, CE MRA. In three volunteers, injection rates of 0.5, 1.5 and 3.0 mL/second were administered in a randomized order and imaged in two separate sessions. Contrast agent bolus dynamics measured in volunteers were used in computer simulations to confirm variations in contrast agent concentration as a source of vessel ringing and blurring artifacts. To validate the effect of injection rate in pathologic vessels, 37 patients with peripheral vascular disease were imaged with a time-resolved technique using an injection rate of 0.5 mL/second or 1.5 mL/second and retrospectively divided into two groups. In volunteers, higher injection rates caused a stronger modulation of k-space and resulted in increased ringing artifacts in time-resolved CE MRA. These results were reproduced with computer simulations. In the qualitative patient study, significantly less vessel blurring was observed using a lower injection-rate, without a significant loss of vessel contrast.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Angiografía por Resonancia Magnética
/
Medios de Contraste
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Pierna
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Qualitative_research
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Magn Reson Imaging
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos