Interactions of surfactants with living cells. Induction of apoptosis by detergents containing a beta-lactam moiety.
Amino Acids
; 21(2): 185-94, 2001.
Article
en En
| MEDLINE
| ID: mdl-11665814
ABSTRACT
The toxicity of new surfactants containing a beta-lactam ring has been established by studying their interaction with a hybridoma cell line. An hour of contact is sufficient to generate an apoptotic signal after two days of culture. Under the experimental conditions chosen for the experiments, surfactants have been divided into three categories i) biocompatible and non-apogenic; ii) surfactants triggering an apoptotic signal without inducing cell necrosis; iii) surfactants triggering an apoptotic signal at low concentrations and destroying the cells by necrosis at higher concentrations. The necrosis inducing surfactants also had haemolytic properties. These properties were related to the values of the hydrophilic-lipophilic balance of the molecules.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tensoactivos
/
Apoptosis
/
Beta-Lactamas
/
Detergentes
/
Eritrocitos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Amino Acids
Asunto de la revista:
BIOQUIMICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia