Improving axonal growth and functional recovery after experimental spinal cord injury by neutralizing myelin associated inhibitors.
Brain Res Brain Res Rev
; 36(2-3): 204-12, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11690617
ABSTRACT
Injuries of the spinal cord often result in an irretrievable loss of motor and sensory functions of all body parts situated below the lesion site. Functional recovery is restricted mainly due to the limited regeneration and plasticity of injured axons in the adult central nervous system. Over the last few years different experimental approaches have led to axonal growth and functional benefits in animal models. This review focuses on the effects of the neutralization of myelin-associated neurite growth inhibitors, in particular Nogo-A, using the monoclonal antibody IN-1. Acute mAb IN-1 treatment of adult CNS lesioned rats results in extensive plastic changes of neuronal connections and regenerative fiber growth. In two different lesion paradigms (i.e. pyramidal tract lesion and incomplete spinal cord lesion in adult rats), the mAb IN-1-treated animals always showed a higher degree of recovery in various behavioral tests. These observations, together with electrophysiological results, suggest that neuronal CNS circuits of mAb IN-1-treated animals can be rearranged, and that sprouting and regenerating axons form functionally meaningful connections.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Médula Espinal
/
Traumatismos de la Médula Espinal
/
Conos de Crecimiento
/
Recuperación de la Función
/
Anticuerpos Monoclonales
/
Proteínas de la Mielina
/
Regeneración Nerviosa
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Brain Res Brain Res Rev
Asunto de la revista:
CEREBRO
Año:
2001
Tipo del documento:
Article
País de afiliación:
Suiza