Surfactant protein A expression in human normal and neoplastic breast epithelium.
Am J Clin Pathol
; 116(5): 721-8, 2001 Nov.
Article
en En
| MEDLINE
| ID: mdl-11710690
ABSTRACT
We studied the presence of surfactant protein A (Sp-A) immunoreactivity and messenger RNA in 62 normal and abnormal breast samples. Sections were immunostained with polyclonal anti-Sp-A antibody. The association between Sp-A immunoreactivity and histologic grade of 32 invasive ductal carcinomas was assessed by 3 pathologists who scored the intensity of Sp-A immunoreactivity times the percentage of tumor immunostained; individual scores were averaged, and the final scores were correlated with tumor grade, proliferative index, and expression of estrogen and progesterone receptors. Strong Sp-A immunoreactivity was present at the luminal surface of ductal epithelial cells in normal breast samples and in benign lesions; carcinomas displayed variable immunoreactivity, inversely proportional to the degree of differentiation. Sp-A messenger RNA was detected by reverse transcriptase-polymerase chain reaction in 3 of 3 normal breast samples and 9 of 9 carcinomas. The significance of Sp-A expression in breast epithelium requires further study; possibly it has a role in native host defense or epithelial differentiation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteolípidos
/
Surfactantes Pulmonares
/
Mama
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Neoplasias de la Mama
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Carcinoma Intraductal no Infiltrante
Límite:
Female
/
Humans
Idioma:
En
Revista:
Am J Clin Pathol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
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SCOTLAND
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UK
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UNITED KINGDOM