Priming of CTL responses by DNA vaccines: direct transfection of antigen presenting cells versus cross-priming.
Dev Biol (Basel)
; 104: 9-14, 2000.
Article
en En
| MEDLINE
| ID: mdl-11713829
ABSTRACT
DNA vaccines can induce cytotoxic T lymphocyte (CTL) responses in various species including mice, non-human primates and humans. It is now well established that antigen presenting cells (APCs) are required for induction of these responses. However, it is not yet known whether this is a function of antigen expression within or acquisition of antigen by these cells, or a combination of both. Cross-priming has been demonstrated to occur from cells (including muscle cells) to APCs in vivo. In addition, there is evidence that APCs can be transfected after DNA vaccination. Hence, efforts to facilitate cross-priming and to increase transfection of APCs will be important for increasing the potency of DNA vaccines.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T Citotóxicos
/
Vacunas de ADN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Dev Biol (Basel)
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND