Preparation of 5-substituted 1H-tetrazoles from nitriles in water.
J Org Chem
; 66(24): 7945-50, 2001 Nov 30.
Article
en En
| MEDLINE
| ID: mdl-11722189
ABSTRACT
The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts. The scope of the reaction is quite broad; a variety of aromatic nitriles, activated and unactivated alkyl nitriles, substituted vinyl nitriles, thiocyanates, and cyanamides have all been shown to be viable substrates for this reaction.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tetrazoles
/
Nitrilos
Idioma:
En
Revista:
J Org Chem
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos