Glycoside in schizophrenic patients sera affects behavior of mouse forced swimming.
Tohoku J Exp Med
; 194(4): 223-8, 2001 Aug.
Article
en En
| MEDLINE
| ID: mdl-11725838
ABSTRACT
We found a glycoside in sera of schizophrenic patients. This glycoside increased climbing of mouse forced swimming and the climbing was decreased by dopamine D1 receptor antagonist SCH-23390 with a dose dependent manner. This glycoside had much reactivity of GalNAc alpha1-3GalNAc, but not that of polymannoses nor that of Gal beta1-3GlcNAc alpha1-serine or threonine. This strongly suggests that the glycoside is an isolated O-glycoside, but not N-glycoside nor O-glycoside having core 1 or 2. The present findings suggest that schizophrenic patients have the special glycoside affecting the D1 receptor activity in their serum.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Conducta Animal
/
Glicósidos
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Tohoku J Exp Med
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón