Expression of brain subtype creatine kinase in the zebrafish embryo.
Mech Dev
; 109(2): 409-12, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11731259
ABSTRACT
Creatine kinases (CK) play crucial roles in intracellular energy transfer. We have isolated a cDNA from zebrafish embryos, which encodes a CK highly related to the mammalian brain subtype creatine kinase (BCK). The bck mRNA is expressed maternally in the zebrafish embryo and transcripts are distributed uniformly in blastula and gastrula stages. Expression becomes restricted to the prechordal plate and the nervous system during subsequent somitogenesis stages. bck transcripts are abundant in primary neurons in the developing central nervous system of the 1-day-old embryo. While some bck expression persists in the hindbrain, expression vanishes in the spinal cord of the 2-day-old embryo. In summary, the expression pattern of bck is highly dynamic and suggests a role for bck during gastrulation and neuronal differentiation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Creatina Quinasa
/
Isoenzimas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mech Dev
Asunto de la revista:
EMBRIOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia