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Cerebral and regional organ perfusion in pigs during xenon anaesthesia.
Schmidt, M; Marx, T; Kotzerke, J; Lüderwald, S; Armbruster, S; Topalidis, P; Schirmer, U; Reinelt, H.
Afiliación
  • Schmidt M; Department of Cardiac Anaesthesia, University of Ulm, Ulm, Germany.
Anaesthesia ; 56(12): 1154-9, 2001 Dec.
Article en En | MEDLINE | ID: mdl-11736770
Little is known about the haemodynamic effects of inhaled xenon on regional organ perfusion. The aim of this study was to investigate the effect of 79% xenon ventilation on organ perfusion in pigs. We investigated 10 pigs, which were randomly allocated to receive either xenon 79% or total intravenous anaesthesia (TIVA)/oxygen anaesthesia. Microspheres were used to determine organ perfusion. The following regions of interest were investigated: cerebral cortex, medulla oblongata, brainstem, cerebellum, liver, kidney, small intestine, colon, muscle, skin and heart. The results demonstrated a significant increase in regional perfusion in the brainstem (+63%), cerebral cortex (+38%), medulla oblongata (+35%) and cerebellum (+34%). All other organs showed no significant change in regional perfusion. We conclude that xenon should be used with caution in clinical situations associated with pathological increases in intracranial pressure, e.g. neurosurgical procedures, head injury, cerebral mass lesions or stroke.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Xenón / Circulación Cerebrovascular / Anestésicos por Inhalación / Hemodinámica Límite: Animals Idioma: En Revista: Anaesthesia Año: 2001 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Xenón / Circulación Cerebrovascular / Anestésicos por Inhalación / Hemodinámica Límite: Animals Idioma: En Revista: Anaesthesia Año: 2001 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido