Central chemosensitivity and breathing asleep in unilateral medullary lesion patients: comparisons to animal data.
Respir Physiol
; 129(1-2): 269-77, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11738660
ABSTRACT
The rostro-ventrolateral medulla (RVLM) is a site of chemosensitivity in animals; such site(s) have not been defined in humans. We studied the effect of unilateral focal lesions in the rostrolateral medulla (RLM) of man, on the ventilatory CO(2) sensitivity and during awake and sleep breathing. Nine patients with RLM lesions (RLM group), and six with lesions elsewhere (non-RLM group) were studied. The ventilatory CO(2) sensitivity was lower in the RLM compared with the non-RLM group (mean (S.D.), RLM, 1.4 (0.9), non-RLM 3.0 (0.6) L min(-1) mmHg(-1)). In both groups resting breathing was normal. During sleep all RLM patients had frequent arousals, four had significant sleep disordered breathing (SDB), only one non-RLM patient had SDB. Our findings in humans resemble those in animals with focal RVLM lesions. This review provides evidence that in humans there is an area of chemosensitivity in the RLM. We propose that in humans, dorsal displacement of the RVLM area of chemosensitivity in animals, arises from development of the olive plus the consequences of the evolution of the cerebellum/inferior peduncle.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Respiración
/
Sueño
/
Encéfalo
/
Encefalopatías
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Bulbo Raquídeo
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Células Quimiorreceptoras
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Respir Physiol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Reino Unido