Quinine-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: frequency, clinical features, and long-term outcomes.
Ann Intern Med
; 135(12): 1047-51, 2001 Dec 18.
Article
en En
| MEDLINE
| ID: mdl-11747383
ABSTRACT
BACKGROUND:
Quinine-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) is thought to be uncommon and to have a good prognosis.OBJECTIVE:
To describe the frequency, clinical features, and long-term outcomes of quinine-associated TTP-HUS.DESIGN:
Case series.SETTING:
Hospitals in central-western Oklahoma. PATIENTS 225 consecutive patients with TTP-HUS, 1989-2000. MEASUREMENTS Presenting features and clinical outcomes.RESULTS:
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome was associated with quinine in 17 patients. Four patients died, and 7 survivors currently have chronic renal failure. Since 1 July 1995, 132 patients with clinically suspected TTP-HUS were explicitly asked about drug exposure. Fourteen (11%) had taken quinine, and 7 had taken other drugs associated with TTP-HUS. Neurologic abnormalities were as severe in patients with quinine-associated TTP-HUS as in the 118 patients who had not taken quinine.CONCLUSIONS:
Quinine is a common cause of drug-associated TTP-HUS and can cause death and chronic renal failure. When the disorder is described as TTP-HUS rather than only as HUS, the severity of neurologic abnormalities and the occasional absence of renal failure are emphasized. If recurrent disease is to be prevented, clinicians must recognize quinine as a possible cause.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Púrpura Trombocitopénica Trombótica
/
Quinina
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Síndrome Hemolítico-Urémico
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Relajantes Musculares Centrales
Tipo de estudio:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Ann Intern Med
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos