Structural and functional characterization of a monoclonal antibody specific for the preS1 region of hepatitis B virus.
FEBS Lett
; 509(3): 463-8, 2001 Dec 14.
Article
en En
| MEDLINE
| ID: mdl-11749974
ABSTRACT
The monoclonal antibody 5a19, raised against the ay serotype of hepatitis B virus, binds to the segment of the preS1 region comprising residues 37-43, which is implicated in attachment of the virus to hepatocytes. The dissociation constant, derived from kinetic studies using surface plasmon resonance techniques, is in the low nanomolar range. The nucleotide sequence of the variable domains has been determined and the corresponding germ-line genes have been identified. The three-dimensional structure of the Fab fragment has been determined by X-ray crystallography to 2.6 A resolution.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Precursores de Proteínas
/
Antígenos de Superficie de la Hepatitis B
/
Anticuerpos Monoclonales
/
Anticuerpos Antivirales
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM