Gene induction during differentiation of human monocytes into dendritic cells: an integrated study at the RNA and protein levels.
Funct Integr Genomics
; 1(5): 323-9, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11793251
ABSTRACT
Changes in gene expression occurring during differentiation of human monocytes into dendritic cells were studied at the RNA and protein levels. These studies showed the induction of several gene classes corresponding to various biological functions. These functions encompass antigen processing and presentation, cytoskeleton, cell signalling and signal transduction, but also an increase in mitochondrial function and in the protein synthesis machinery, including some, but not all, chaperones. These changes put in perspective the events occurring during this differentiation process. On a more technical point, it appears that the studies carried out at the RNA and protein levels are highly complementary.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Dendríticas
/
ARN
/
Monocitos
/
Proteínas
/
Diferenciación Celular
Límite:
Humans
Idioma:
En
Revista:
Funct Integr Genomics
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia