[Association of HLA-DRB1 allele and the susceptibility to alveolar echinococcosis in the west of China].
Zhonghua Yi Xue Za Zhi
; 80(6): 414-6, 2000 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-11798795
ABSTRACT
OBJECTIVE:
To investigat the association of HLA-DRB1 alleles and the susceptibility to alveolar echinococcosis (AE).METHODS:
Thirty-five patients with AE in the high prevalence areas in the west of China were investigated for HLA-DRB1 gene by PCR/SSP technique. The results were compared with 104 normal healthy peoples.RESULTS:
Frequency of HLA-DRB1 * 040x was 26% in patient group, which was significantly higher than in control group (9.62%), with a relative risk (RR) of 4.45 (chi(2) = 13.67, P < 0.01), and with an etiological fraction of 0.20. Frequency of HLA-DRB1 * 0701 allele was decreased in patient group (patient 2.86%, control 13.94%; chi(2) = 6.67, P < 0.05), with preventable fraction of 0.30. While the frequencies of other DRB1 alleles were not significantly different.CONCLUSION:
Susceptibility to AE is strongly associated with the HLA-DRB1 * 040x allele. The high prevalence of human AE in this region was associated with genetic factor. HLA-DRB1 * 0701 geners resistant to Echinococcus multilocularis metacestode infection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos HLA-DR
/
Equinococosis Hepática
/
Alelos
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Año:
2000
Tipo del documento:
Article
País de afiliación:
China