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Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report.
Mohty, M; Faucher, C; Gaugler, B; Vey, N; Sainty, D; Arnoulet, C; Mozziconacci, M J; Isnardon, D; Gastaut, J A; Maraninchi, D; Olive, D; Blaise, D.
Afiliación
  • Mohty M; Laboratoire d'Immunologie des Tumeurs, Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France.
Bone Marrow Transplant ; 28(12): 1157-60, 2001 Dec.
Article en En | MEDLINE | ID: mdl-11803360
ABSTRACT
We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo 14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Trasplante de Médula Ósea / Efecto Injerto vs Tumor / Linfocitosis Límite: Humans / Male / Middle aged Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2001 Tipo del documento: Article País de afiliación: Francia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Trasplante de Médula Ósea / Efecto Injerto vs Tumor / Linfocitosis Límite: Humans / Male / Middle aged Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2001 Tipo del documento: Article País de afiliación: Francia