Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report.
Bone Marrow Transplant
; 28(12): 1157-60, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11803360
ABSTRACT
We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo 14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Trasplante de Médula Ósea
/
Efecto Injerto vs Tumor
/
Linfocitosis
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Bone Marrow Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia