Indole and beta-carboline alkaloids from Geissospermum sericeum.
J Nat Prod
; 65(1): 85-8, 2002 Jan.
Article
en En
| MEDLINE
| ID: mdl-11809075
ABSTRACT
The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
/
Carbolinas
/
Antimaláricos
Límite:
Animals
/
Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Nat Prod
Año:
2002
Tipo del documento:
Article
País de afiliación:
Reino Unido