Variable severity of beta-thalassemia patients of eastern India: effect of alpha-thalassemia and xmnI polymorphism.
Clin Exp Med
; 1(3): 155-9, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11833853
ABSTRACT
Sixty-four thalassemia and E-beta thalassemia patients were studied for factors that modulate the severity of the disease; i.e., mutation of beta-globin gene, presence of alpha-deletion, and presence of an XmnI site at the -158 position of the Gy gene. Presence of alpha-deletion and/or homozygosity for the XmnI site was in general associated with less-severe disease. About 12% of the patients harbored single alpha-gene deletion, and the gene frequency of the XmnI polymophism in these patients is 0.48.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Globinas
/
Desoxirribonucleasas de Localización Especificada Tipo II
/
Talasemia beta
/
Talasemia alfa
/
Mutación
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Clin Exp Med
Asunto de la revista:
MEDICINA
Año:
2001
Tipo del documento:
Article
País de afiliación:
India