Tongkyutang inhibits mast cell-dependent allergic reactions and inflammatory cytokines secretion.
Clin Chim Acta
; 319(1): 35-41, 2002 May 07.
Article
en En
| MEDLINE
| ID: mdl-11922921
ABSTRACT
BACKGROUND:
Tongkyutang (TKT) is an Oriental herbal prescription, which has been successfully applied for the treatment of allergic disorders, mainly allergic-rhinitis in clinical medicine. However, its effect in experimental models remains unknown.METHODS:
In a mouse model, the role of TKT was examined in mast cell-dependent allergic reactions and secretion of inflammatory cytokines.RESULTS:
TKT concentration-dependently inhibited the ear-swelling response induced by intradermal injection of compound 48/80. TKT inhibited the compound 48/80-induced degranulation from mast cells in ear tissue. TKT dose-dependently inhibited the histamine release from the rat peritoneal mast cells by compound 48/80. TKT also showed inhibition of anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction by oral administration. Furthermore, TKT inhibited both IL-1beta and TNF-alpha secretion induced by PMA and A23187, respectively.CONCLUSIONS:
Our findings provide evidence that TKT inhibits the mast cell-dependent allergic reactions and inflammatory cytokines secretion.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
/
Extractos Vegetales
/
Citocinas
/
Anafilaxia
/
Mastocitos
/
Medicina Tradicional de Asia Oriental
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Clin Chim Acta
Año:
2002
Tipo del documento:
Article
País de afiliación:
Corea del Sur