Efficacy of a motilin receptor agonist (ABT-229) for the treatment of gastro-oesophageal reflux disease.
Aliment Pharmacol Ther
; 16(4): 749-57, 2002 Apr.
Article
en En
| MEDLINE
| ID: mdl-11929393
ABSTRACT
BACKGROUND:
ABT-229 is a potent motilin agonist without significant antibiotic activity. It has been shown to improve gastric emptying in humans and to increase lower oesophageal sphincter pressure in cats.AIM:
To assess the efficacy of four different doses of ABT-229 (1.25 mg, 2.5 mg, 5 mg, 10 mg b.d.) compared to placebo in the treatment of gastro-oesophageal reflux disease, and to determine its safety in patients with gastro-oesophageal reflux disease.METHODS:
In a double-blind, multicentre study, 324 patients with heartburn were randomized to receive four different doses of ABT-229 or placebo for 8 weeks. The efficacy was evaluated by Patient Symptom Questionnaire, daily diary, endoscopy and global evaluation of efficacy.RESULTS:
There were no statistically significant improvement scores for any of the ABT-229 treatment groups vs. the placebo group in any of the efficacy parameters. Reflux symptom scores were significantly worse after treatment in the dyspeptic group. ABT-229 appeared to be well tolerated and safe in total daily doses up to 20 mg.CONCLUSION:
ABT-229 appears to have limited, if any, clinical utility in the treatment of gastro-oesophageal reflux disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de la Hormona Gastrointestinal
/
Reflujo Gastroesofágico
/
Eritromicina
/
Receptores de Neuropéptido
Tipo de estudio:
Clinical_trials
Aspecto:
Patient_preference
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Aliment Pharmacol Ther
Asunto de la revista:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos