Physical activity does not mitigate G-protein-related genetic risk for obesity in individuals of African descent.
Eat Weight Disord
; 7(1): 68-71, 2002 Mar.
Article
en En
| MEDLINE
| ID: mdl-11930987
ABSTRACT
The G-protein beta3 subunit 825 TT genotype has been associated with obesity and hypertension. We examined the interaction between the G-protein TT genotype, physical activity and body mass index (BMI) in a cross-sectional study of African immigrants and African Americans. The genotype frequencies were 6.3% CC, 37.7% CT, and 56% TT. After adjusting for potential confounders, BMI was found to be significantly higher in the sedentary than in the physically active participants (p=0.045). There was no statistically significant effect for genotype (p=0.215) or the interaction between genotype and the level of physical activity (p=0.219). However, the individuals with the CC or CT genotype who were physically active had substantially lower BMIs (M+/-SE) (i.e., 25.74+/-2.02) than any of the other groups sedentary CC + CT (30.58+/-1.03), sedentary TT (30.65+/-1.00) or active TT (29.43+/-1.65). Because of the low statistical power of this study, further research is needed to confirm these findings and to explore potential gene-environment/lifestyle interactions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ejercicio Físico
/
Proteínas de Unión al GTP
/
Predisposición Genética a la Enfermedad
/
Población Negra
/
Obesidad
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eat Weight Disord
Asunto de la revista:
GASTROENTEROLOGIA
/
METABOLISMO
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos