Norepinephrine depresses the capsaicin-evoked miniature excitatory postsynaptic currents in substantia gelatinosa of the rat spinal cord.
Neurosci Lett
; 322(2): 99-102, 2002 Apr 05.
Article
en En
| MEDLINE
| ID: mdl-11958853
ABSTRACT
Capsaicin selectively excites nociceptive primary afferent fibers and increases the frequency of glutaminergic miniature excitatory postsynaptic currents (mEPSCs) in the substantia gelatinosa of the spinal dorsal horn. The whole-cell voltage-clamp recording technique was used to examine the effect of norepinephrine (NE) on the capsaicin-induced increase in the frequency of mEPSCs. In the presence of tetrodotoxin, bath application of capsaicin (1 microM) remarkably enhanced the frequency of mEPSCs (295+/-52% of control). Following pretreatment with NE (10 microM), the capsaicin-induced frequency facilitation of mEPSCs was significantly depressed to 151+/-17% of the control. NE-induced depression in capsaicin action was blocked by yohimbine, a selective alpha(2)-adrenergic receptor antagonist, indicating that NE exerts depression by activating the alpha(2)-adrenergic receptor. As the postsynaptic action of NE has been precluded in the present study, the results suggest that NE inhibits nociceptive input at a presynaptic site, the primary afferent terminal, during the nociceptive transmission in the spinal dorsal horn.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sustancia Gelatinosa
/
Capsaicina
/
Norepinefrina
/
Potenciales Postsinápticos Excitadores
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2002
Tipo del documento:
Article