[Transformation of chemical energy in biomolecular systems with hydrogen bonds]. / Mekhanizm transformatsii khimicheskoi énergii v biomolekuliarnykh sistemakh s vodorodnymi sviaziami.
Biofizika
; 47(2): 236-44, 2002.
Article
en Ru
| MEDLINE
| ID: mdl-11969159
ABSTRACT
The mechanism underlying the excitation of the hydrogen bond with ATP hydrolysis was considered. Coulomb interactions of the proton of the hydrogen bond A-H...B with the electrical field of the covalent bond of ADP-P were calculated. It was shown that the electrical field of the covalent bond of ADP-P excites oscillations of the proton in the complex with the hydrogen bond A-H...B and displaces it from the equilibrium towards the covalent bond. The distortion of the potential curve depends on a change in the length of the covalent bond of ADP-P. Adiabatic potentials U0 and UN of the ADP-P system were calculated, which correspond to the ground and excited states of the H-bond proton. It was found that as the length of the bond of ADP-P (rho) increases, the branches of the adiabatic potential U0(rho) and UN(rho) intersect. At the intersection point, the system can transit to the branch UN(rho), which can lead to a reduction of the barrier and a break of the covalent bond of ADP-P. Presumably, this mechanism is universal for processes of transformation of the chemical energy of ATP to the energy of excited hydrogen bond, a mechanism for the maintenance of heat balance and reduction of entropy in a living organism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenosina Trifosfato
Idioma:
Ru
Revista:
Biofizika
Año:
2002
Tipo del documento:
Article
Pais de publicación:
FEDERAÇÃO RUSSA
/
RU
/
RUSIA
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RUSSIA