Arginine supplementation prevents necrotizing enterocolitis in the premature infant.
J Pediatr
; 140(4): 425-31, 2002 Apr.
Article
en En
| MEDLINE
| ID: mdl-12006956
ABSTRACT
OBJECTIVES:
To determine whether supplementation with L -arginine reduces the incidence of all stages of necrotizing enterocolitis (NEC) in premature infants with birth weight < or =1250 g and gestational age < or =32 weeks. STUDYDESIGN:
In a randomized, double-blind, placebo-controlled study, 152 premature infants were prospectively, randomly assigned to receive either supplemental L -arginine (1.5 mmol/kg per day; n =75 [group A]) or placebo (control group; n = 77 [group B]) with oral feeds/parenteral nutrition during the first 28 days of life. Nutrient intake, plasma ammonia, arginine, and amino acid concentrations were measured in all infants at days 3, 14, and 28 and at the time of diagnosis of NEC.RESULTS:
NEC developed in 5 infants in group A compared with 21 infants in group B (P <.001). Arginine intake and plasma arginine concentrations were similar in both groups at study entry and (as expected) increased in group A at days 14 and 28. Plasma arginine concentrations were lower in both groups at time of diagnosis of NEC. No significant differences in maternal and neonatal demographics, nutrient intake, plasma ammonia and total and essential amino acid concentrations were present between the two groups.CONCLUSIONS:
Arginine supplementation (1.5 mmol/kg per day) in premature infants reduces the incidence of all stages of NEC.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arginina
/
Recien Nacido Prematuro
/
Suplementos Dietéticos
/
Enterocolitis Necrotizante
Tipo de estudio:
Clinical_trials
/
Incidence_studies
/
Prognostic_studies
Límite:
Female
/
Humans
/
Male
/
Newborn
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Pediatr
Año:
2002
Tipo del documento:
Article
País de afiliación:
Canadá