Haemoglobin C/alpha thalassaemia: haematological and biosynthetic studies.
Br J Haematol
; 30(3): 337-42, 1975 Jul.
Article
en En
| MEDLINE
| ID: mdl-1201216
ABSTRACT
A family with genes for haemoglobin C (Hb C) and alpha thalassaemia was studied. The mother had Hb-C trait. The father also had Hb-C trait but in addition displayed microcytosis, elevated Hb-F levels and a concentration of Hb-C less than usual for heterozygotes. The proband was homozygous for Hb-C but had Hb-F levels far exceeding those present in Hb-C disease. Biosynthetic studies of globin synthesis in both father and daughter showed a deficit of alpha chains relative to non-alpha chains, confirming the presence of alpha thalassaemia. The coexistence of alpha thalassaemia influences the level of mutant haemoglobin in haemoglobinopathies in which Hb C is present, in a fashion similar to that observed in sickle-cell trait.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Talasemia
/
Enfermedad de la Hemoglobina C
Límite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Br J Haematol
Año:
1975
Tipo del documento:
Article