Virus markers associated with vertical transmission of human T lymphotropic virus type 1 in Jamaica.
Clin Infect Dis
; 34(12): 1551-7, 2002 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-12032888
ABSTRACT
In a prospective study involving 150 mothers and their offspring in Jamaica, we examined maternal viral factors associated with the risk of transmission of human T lymphotropic virus type 1 (HTLV-1). Overall, the incidence of HTLV-1 infection among children was 8.3 occurrences per 1000 person-months. A higher maternal provirus level (odds ratio [OR], 1.9 per quartile) and a higher HTLV-1 antibody titer (OR, 2.2 per quartile) were independently associated with transmission to children, whereas the presence of anti-Tax antibody was not. Higher maternal antibody titers also were associated with older age at infection among children who were breast-fed for =12 months, which suggests that passively transferred maternal antibodies confer protection against infection while they persist. These data imply that mothers who have high provirus loads should be encouraged not to breast-feed. Alternatively, the successful reduction of maternal provirus loads or maintenance of passive antibody levels in infants during breast-feeding may lower the risk of transmission.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus Linfotrópico T Tipo 1 Humano
/
Anticuerpos Anti-HTLV-I
/
Infecciones por HTLV-I
/
Productos del Gen tax
/
Transmisión Vertical de Enfermedad Infecciosa
Tipo de estudio:
Observational_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
País/Región como asunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
Clin Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos