Prognostic relevance of Ki-67 antigen expression in 329 cases of oral squamous cell carcinoma.
ORL J Otorhinolaryngol Relat Spec
; 64(3): 200-5, 2002.
Article
en En
| MEDLINE
| ID: mdl-12037387
ABSTRACT
Prognostic relevance of Ki-67 staining in oral squamous cell carcinomas was investigated by immunohistochemical expression in 329 cases of squamous cell carcinoma of the oral cavity due to a formamide pretreatment. The growth fraction (Ki-67 labelling index, LI) was correlated to histopathological grading, lymphocytic reaction, stroma/tumour proportion, pattern of invasion, mitotic rate, degree of keratinisation, tumour size, thickness of tumor, depth of invasion, lymph node involvement and five-year survival rate. Highly significant inverse correlation was found between the Ki-67 LI, the stroma/tumour proportion and the degree of keratinisation whereas no correlation could be established between the Ki-67 LI and all the other histological and clinical paramters. Ki-67 staining alone has no prognostic relevance in oral cancer.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Antígeno Ki-67
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
ORL J Otorhinolaryngol Relat Spec
Año:
2002
Tipo del documento:
Article
Pais de publicación:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND