[Clinico-hemodynamic study and treatment of 44 patients with primary pulmonary hypertension]. / Estudio clínico-hemodinámico y tratamiento de 44 pacientes con hipertensión pulmonar primaria.
Med Clin (Barc)
; 118(20): 761-6, 2002 Jun 01.
Article
en Es
| MEDLINE
| ID: mdl-12049690
ABSTRACT
BACKGROUND:
Primary pulmonary hypertension is a poorly understood disease with a difficult treatment. PATIENTS ANDMETHOD:
Retrospective study of a series of 44 patients suffering from pulmonary hypertension who were studied in our center between 1992 and 2000.RESULTS:
At diagnosis, 6 (13%) patients were classified as having NYHA functional class I, 11 (25%) had class II, 25 (57%) had class III, and 2 had class IV. Mean pulmonary artery systolic pressure by echo-doppler was 92 (range 43-154) mmHg. Basal right catheterization showed a mean (SD) pulmonary artery pressure of 58 (18) mmHg, total basal pulmonary resistances of 1679 (1,071) din/cm2 and cardiac index of 2.2 (1) 1/minute/m2. Five patients improved with anticoagulation and calcium channel blockers therapy. Since 1998, 11 patients had been treated with continuous endovenous epoprostenol, yet only 3 (27%) had significant clinical improvement. Survival at 5 years after diagnosis was 56%. At the end of study, 7 (70%) out of 10 patients who underwent pulmonary transplantation were alive (mean 34, range 3-62 months).CONCLUSIONS:
Pulmonary hypertension is a disease with a poor prognosis. However, treatment with prostaglandins and pulmonary transplantation may lead to encouraging results.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipertensión Pulmonar
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
Es
Revista:
Med Clin (Barc)
Año:
2002
Tipo del documento:
Article
País de afiliación:
España