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In vivo evaluation of matrix pellets containing nanocrystalline ketoprofen.
Vergote, G J; Vervaet, C; Van Driessche, I; Hoste, S; De Smedt, S; Demeester, J; Jain, R A; Ruddy, S; Remon, J P.
Afiliación
  • Vergote GJ; Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium.
Int J Pharm ; 240(1-2): 79-84, 2002 Jun 20.
Article en En | MEDLINE | ID: mdl-12062503
The aim of this study was to evaluate the in-vivo behaviour of matrix pellets formulated with nanocrystalline ketoprofen after oral administration to dogs. No significant differences in AUC-values were seen between pellet formulations containing nanocrystalline or microcrystalline ketoprofen and a commercial ketoprofen formulation (reference: Rofenid 200 Long Acting). C(max) of the formulations containing nano- or microcrystalline ketoprofen was significantly higher compared to reference, whereas t(max) was significantly lower. The in-vivo burst release observed for the spray dried nanocrystalline ketoprofen matrix pellets was reduced following compression of the pellets in combination with placebo wax/starch pellets. These matrix tablets sustained the ketoprofen plasma concentrations during 5.6 and 5.4 h for formulations containing nano- and microcrystalline ketoprofen, respectively.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Cetoprofeno / Nanotecnología Límite: Animals Idioma: En Revista: Int J Pharm Año: 2002 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Cetoprofeno / Nanotecnología Límite: Animals Idioma: En Revista: Int J Pharm Año: 2002 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos