The use of levo-alpha-acetylmethadol (LAAM) in methadone patients who have not achieved heroin abstinence.
J Addict Dis
; 21(3): 13-22, 2002.
Article
en En
| MEDLINE
| ID: mdl-12094997
ABSTRACT
Levo-alpha-acetylmethadol (LAAM) pharmacotherapy was offered to twelve patients who continued illicit opioid abuse after > or = eleven months in methadone maintenance treatment. After 6-8 weeks on LAAM, plasma concentrations of the norLAAM metabolite varied significantly by LAAM dosing day, plasma adrenocorticotropin (ACTH) concentrations were significantly increased compared to methadone, and two of the seven subjects remaining in LAAM treatment were free of illicit opioids and nonprescribed methadone. After one year, one of five remaining subjects was using illicit opioids, and three were using non-prescribed methadone. While subject acceptance of LAAM was high, subjects were not in a "steady-state," with evidence of ongoing illicit opioid abuse.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dependencia de Heroína
/
Metadona
/
Acetato de Metadil
/
Narcóticos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Addict Dis
Asunto de la revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos