Influence of threonine exporters on threonine production in Escherichia coli.
Appl Microbiol Biotechnol
; 59(2-3): 205-10, 2002 Jul.
Article
en En
| MEDLINE
| ID: mdl-12111147
ABSTRACT
Threonine production in Escherichia coli threonine producer strains is enhanced by overexpression of the E. coli rhtB and rhtC genes or by heterologous overexpression of the gene encoding the Corynebacterium glutamicum threonine excretion carrier, thrE. Both E. coli genes give rise to a threonine-resistant phenotype when overexpressed, and they decrease the accumulation of radioactive metabolites derived from [(14)C] L-threonine. The evidence presented supports the conclusion that both RhtB and RhtC catalyze efflux of L-threonine and other structurally related neutral amino acids, but that the specificities of these two carriers differ substantially.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Treonina
/
Proteínas Bacterianas
/
Proteínas de Escherichia coli
/
Sistemas de Transporte de Aminoácidos Neutros
/
Escherichia coli
Idioma:
En
Revista:
Appl Microbiol Biotechnol
Año:
2002
Tipo del documento:
Article
País de afiliación:
Alemania