Effects of human neutrophil peptide-1 on the expression of interstitial collagenase and type I collagen in human dermal fibroblasts.
Arch Dermatol Res
; 294(4): 185-9, 2002 Jul.
Article
en En
| MEDLINE
| ID: mdl-12111349
ABSTRACT
Human neutrophil peptide-1 (HNP-1), a defensin with antimicrobial properties, is also thought to promote wound healing. To elucidate the mechanism by which wound healing is facilitated by this factor, we investigated the effect of HNP-1 on the expression of interstitial collagenase (matrix metalloproteinase 1, MMP-1), collagen types I and III, and tissue inhibitor of metalloproteinase 1 (TIMP-1) by cultured fibroblasts by means of RT-PCR and ELISA. Our results showed that synthetic HNP-1 increased the expression of proalpha1(I) collagen mRNA and protein. In contrast, the expression of MMP-1 was decreased at both the mRNA and protein levels. Our observations suggest that HNP-1 may promote wound repair by enhancing extracellular matrix deposition and by controlling its degradation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Metaloproteinasa 1 de la Matriz
/
Alfa-Defensinas
/
Colágeno Tipo I
Límite:
Humans
Idioma:
En
Revista:
Arch Dermatol Res
Año:
2002
Tipo del documento:
Article
País de afiliación:
Japón