Macaque animal model for HIV-induced neurological disease.
J Neural Transm (Vienna)
; 109(5-6): 747-66, 2002 May.
Article
en En
| MEDLINE
| ID: mdl-12111465
ABSTRACT
The pathogenesis of HIV-induced neurological disorders is still incompletely understood. Since many aspects of this disease are difficult to explore in humans, animal models are necessary to fill the gaps in our knowledge. Based on the high concordance with the human system, the SIV-infection of macaques currently provides the best animal model to study pathogenesis, therapy and prevention of HIV-infection. In this review, important features of the CNS-infection in this model are outlined. Recent virological, immunological, neurophysiological and neurochemical findings obtained with this animal model are presented and key factors in the development of neurological disease are identified.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encefalopatías
/
Síndrome de Inmunodeficiencia Adquirida del Simio
/
Complejo SIDA Demencia
/
Enfermedades de los Primates
/
Modelos Animales de Enfermedad
/
Macaca
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neural Transm (Vienna)
Año:
2002
Tipo del documento:
Article