Cholera toxin B subunit labeling in lamina II of spinal cord dorsal horn following chronic inflammation in rats.
Neurosci Lett
; 327(3): 161-4, 2002 Jul 26.
Article
en En
| MEDLINE
| ID: mdl-12113902
ABSTRACT
We have investigated the effect of inflammation on the labeling pattern of cholera toxin B subunit (CTB)-conjugated horseradish peroxidase, an A-fiber marker, by an intra-sciatic nerve injection of the tracer. Following chronic inflammation in one hind paw in rats, there was substantial CTB labeling in lamina II of the spinal dorsal horn, which is normally absent. However, there was no change in the labeling pattern of wheat germ agglutinin or fluoride resistant acid phosphatase/thiamine monophosphatase, two C-fiber markers. The CTB labeling in lamina II after peripheral nerve injury has been interpreted as central sprouting of A-fibers or uptake of the tracer by injured C-fibers. Our results suggest that chronic inflammation and nerve injury may share some common mechanisms in generating allodynia and hyperalgesia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nervio Ciático
/
Coloración y Etiquetado
/
Toxina del Cólera
/
Células del Asta Posterior
/
Inflamación
/
Fibras Nerviosas
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2002
Tipo del documento:
Article
País de afiliación:
Reino Unido