Catalytic oxidations of steroid substrates by artificial cytochrome p-450 enzymes.
J Org Chem
; 67(15): 5057-67, 2002 Jul 26.
Article
en En
| MEDLINE
| ID: mdl-12126389
ABSTRACT
Catalysts comprising manganese-porphyrins carrying cyclodextrin binding groups are able to perform hydroxylations with substrate selectivity and regio- and stereoselectivity and high catalytic turnovers. The geometries of the catalyst/substrate complexes override intrinsic substrate reactivities, permitting attack on geometrically accessible saturated carbons of steroids in the presence of secondary carbinol groups and carbon-carbon double bonds, as in enzymatic reactions. Selective hydroxylations of steroid carbon 9 positions are of particular practical interest.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Porfirinas
/
Sistema Enzimático del Citocromo P-450
/
Manganeso
Idioma:
En
Revista:
J Org Chem
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos