[Detection of nucleic acids in stomach and duodenal contents in patients with gastroduodenal pathology]. / Metodika opredeleniia nukleinovykh kislot v fazakh zheludochnogo i duodenal'nogo soderzhimogo u bol'nykh s patologiei gastroduodenal'noi sistemy.

ABSTRACT

The proposed method shows the velocity of gastroduodenal epitheliocyte exchange by evaluating the total content of nucleic acids in gastric and duodenal aspirates. The concentration of nucleic acids in the cavitary secretion phase reflects the state of the gastroduodenal mucosa and physicochemical properties of the mucus. Sixty patients with gastroduodenal diseases (chronic gastritis, chronic duodenitis from surface to atrophic and during exacerbation) were examined. Changes in the distribution of nucleic acids by phases of cavitary secretion were revealed. A decrease in the total content of nucleic acids in cavitary contents was paralleled by decreased activity of chronic gastritis and duodenitis and normalization of colloid and gel-forming properties of the mucus, which manifested by an essential increase of nucleic acids concentrations in the mucus and decrease in the gastric juice.