cDNA Cloning of the Cytoplasmic Domain of Growth Hormone Receptor from guinea Pig and Homology Comparison.

ABSTRACT

The evolutionary position of guinea pig has not been unequivocally clarified, and it appears to show abnormalities in GH response. The cDNA of GHR cytoplasmic domain from guinea pig was cloned and sequenced. By homology comparison, it was found that the sequence we obtained was different markedly from that of rat or mouse. The results provided not only the molecular biology evidence for clarifying the evolutionary position of guinea pig, but also a basis to determine the complete cDNA sequence of GHR from guinea pig and to understand its cytoplasmic signal transduction.