Activation of capsaicin receptors on the sciatic nerve induces FOS expression in the spinal dorsal horn of adult rats.
Neurosignals
; 11(3): 151-7, 2002.
Article
en En
| MEDLINE
| ID: mdl-12138252
ABSTRACT
By using immunohistochemical staining for FOS protein in the spinal cord, the role of capsaicin receptors on the sciatic nerve was investigated. After topical application of capsaicin (1%) to the sciatic nerve, FOS-like immunoreactive (FOS-LI) neurons were observed, chiefly in the superficial laminae of the lumbar dorsal horn. Topical application of capsazepine (5%) or lidocaine (2%) to the sciatic nerve for 15 min before the application of capsaicin reduced the number of FOS-LI neurons in the superficial dorsal horn (by 83.2 +/- 1.7 and 32.4 +/- 1.2%, respectively). One week after pretreatment of the sciatic nerve with colchicine, the number of FOS-LI neurons induced by capsaicin was greatly decreased (by 74.6 +/- 1.7%). Given that FOS protein expression after peripheral noxious stimulation is found in a location similar to that in the present study, our results indicate that the capsaicin receptor on the sciatic nerve is involved in the transmission of noxious information.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Droga
/
Nervio Ciático
/
Capsaicina
/
Regulación de la Expresión Génica
/
Proteínas Proto-Oncogénicas c-fos
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Células del Asta Posterior
/
Fibras Nerviosas
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
Neurosignals
Asunto de la revista:
NEUROLOGIA
Año:
2002
Tipo del documento:
Article