Impact of six months of GnRH agonist therapy for endometriosis. Is there an age-related effect on bone mineral density?
J Reprod Med
; 47(7): 530-4, 2002 Jul.
Article
en En
| MEDLINE
| ID: mdl-12170527
ABSTRACT
OBJECTIVE:
To determine if there is an age-related effect on bone mineral density (BMD) loss with GnRH agonist treatment of endometriosis and, in particular, whether the impact of this therapy in terms of BMD loss is different if it is used at an age prior to attainment of peak BMD than after attaining it. STUDYDESIGN:
Data from a randomized, double-placebo-controlled clinical trial comparing efficacy and safety of two GnRH agonists, without add-back, for the treatment of endometriosis, were analyzed.RESULTS:
No significant age-related effect was detected for either GnRH agonist on absolute BMD loss with a single, six-month course. However, in women at an age prior to peak BMD, prevention of the natural increase in BMD with these drugs may prevent women from attaining their peak BMD and thus increase their risk of osteoporosis in later life.CONCLUSION:
GnRH agonists should be used with caution and perhaps only with strategies designed to minimize the impact on BMD in women prior to attainment of peak BMD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Hormona Liberadora de Gonadotropina
/
Leuprolida
/
Nafarelina
/
Endometriosis
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Reprod Med
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos