[Possible etiological role retroviruses and enteroviruses in the development of amyotrophic lateral sclerosis]. / Mogelijke etiologische rol van retrovirussen en enterovirussen bij het ontstaan van amyotrofische laterale sclerose.
Ned Tijdschr Geneeskd
; 146(30): 1398-400, 2002 Jul 27.
Article
en Nl
| MEDLINE
| ID: mdl-12174431
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with unknown pathogenesis. Loss of motor neurons leads to progressive weakness and, finally, respiratory failure with a mean survival of 3 years. A possible causal role of a retroviral infection has recently been suggested by studies of 7 HIV-infected patients who developed a rapid progressive ALS-like disorder as the first manifestation of their HIV-infection. All patients stabilised or improved with antiretroviral therapy. Other research groups have published on the detection of enterovirus RNA in the spinal cords of ALS-patients, also suggesting a viral aetiology of the disease. The results of these neuro-virological studies warrant further research into the possible role of viral infections as a cause of ALS, as well as clinical trials with anti-retroviral and anti-enteroviral drugs in ALS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Retroviridae
/
Infecciones por Enterovirus
/
Esclerosis Amiotrófica Lateral
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Año:
2002
Tipo del documento:
Article
Pais de publicación:
Países Bajos