T594M mutation of the beta-subunit of the epithelial sodium channel in Ghanaian populations from Kumasi and London and a possible association with hypertension.
Genet Test
; 6(1): 63-5, 2002.
Article
en En
| MEDLINE
| ID: mdl-12180079
ABSTRACT
We have tested 186 individuals from Ghana, 95 indigenous and 91 who have settled in the United Kingdom, for the presence of the T594M mutation in the beta-subunit of the epithelial sodium channel, which is associated with hypertension in black populations. The group living in Ghana had a mean age of 27 years and were normotensive, but had an increased frequency of the T allele compared to the London-based population. If this is reflected in larger studies, and the link with hypertension is maintained in the Ghanaian population, this mutation could be a significant cause of hypertension in Ghana.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Canales de Sodio
/
Mutación Missense
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Africa
/
Europa
Idioma:
En
Revista:
Genet Test
Asunto de la revista:
GENETICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Reino Unido