Progress toward a peptidomimetic of laminin-derived pentapeptide YIGSR: synthesis of the unique tricyclic core structure.
J Org Chem
; 67(17): 6097-103, 2002 Aug 23.
Article
en En
| MEDLINE
| ID: mdl-12182648
ABSTRACT
The peptide sequence YIGSR, a segment of the basement membrane matrix glycoprotein laminin, has been identified as a key component in tumor cell invasion. Guided by extensive NMR work and de novo design algorithms, a nonpeptide mimetic of this pentapeptide was identified as a lead candidate for synthesis. The target displays the key amino acid side chains from a novel tricyclic scaffold. The first synthesis of this unique scaffold is completed in 11 steps and 7% overall yield.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Laminina
Idioma:
En
Revista:
J Org Chem
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos