Dietary lipids alter the effect of steroids on the uptake of lipids following intestinal resection in rats.
Dig Dis Sci
; 47(8): 1686-96, 2002 Aug.
Article
en En
| MEDLINE
| ID: mdl-12187929
ABSTRACT
Steroids alter the transport function of the intestine. This study was undertaken to assess the effect of glucocorticosteroids on lipid uptake in rats fed either a saturated (SFA) or a polyunsaturated fatty acid (PUFA) diet. Sprague-Dawley rats underwent transection or 50% resection of the small intestine. The steroids had no effect on the uptake of lipids. However, resection decreased the jejunal uptake of palmitic acid in animals fed SFA and increased the jejunal uptake of palmitic and linoleic acids in those fed PUFA. In animals undergoing intestinal resection, fed SFA, and given control vehicle, there was a reduction in jejunal proglucagon mRNA expression as compared to those fed chow or PUFA. Ornithine decarboxylase (ODC) mRNA expression in the jejunum of resected animals was reduced. In summary, dietary lipids modify the uptake of lipids in resected animals and ODC and proglucagon may be involved in this adaptive response.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prednisona
/
Grasas de la Dieta
/
Metabolismo de los Lípidos
/
Absorción Intestinal
/
Intestino Delgado
Límite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Año:
2002
Tipo del documento:
Article
País de afiliación:
Canadá