Vaccination of corticosteroid immunosuppressed mice against invasive pulmonary aspergillosis.
J Infect Dis
; 186(6): 869-71, 2002 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-12198627
ABSTRACT
Invasive pulmonary aspergillosis is an emerging devastating infection in the immunocompromised host that is treated with corticosteroids for neoplastic disease or for organ transplantation. By use of a model of invasive pulmonary aspergillosis in corticosteroid-treated CF-1 mice, prior infection and 2 Aspergillus fumigatus vaccine preparations (sonicate and filtrate) administered intranasally and subcutaneously were tested for efficacy in protecting against subsequent lethal A. fumigatus infection. The mortality rates were as follows control subjects, 100%; prior infection, 12.5%; sonicate administered intranasally, 29%; sonicate given subcutaneously, 0%; filtrate given intranasally, 75%; and filtrate given subcutaneously, 50%. Prior infection and A. fumigatus sonicate vaccine administered by 2 routes protected corticosteroid-treated animals against subsequent lethal invasive pulmonary aspergillosis. The sonicate vaccine was more protective, but the subcutaneous route was more effective.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aspergilosis
/
Aspergillus fumigatus
/
Vacunas Fúngicas
/
Terapia de Inmunosupresión
/
Vacunación
/
Corticoesteroides
Límite:
Animals
Idioma:
En
Revista:
J Infect Dis
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos