Frequency of CCR5 Gene 32-bp deletion in Pakistani ethnic groups.
Genet Test
; 6(2): 123-7, 2002.
Article
en En
| MEDLINE
| ID: mdl-12215252
ABSTRACT
CCR5 is a G-protein-coupled chemokine receptor that is used as a co-factor by macrophage-tropic (M-tropic) isolates of human immunodeficiency virus-1 (HIV-1) to gain entry into host cells. A 32-bp deletion in the CCR5 gene (CCR5-Delta32) leads to the production of an altered gene product that prevents HIV-1 from entering the host cell. This study was carried out to determine prevalence of CCR5-Delta32 allele frequency in a large Pakistani population sample (n = 821) representing 10 ethnic groups. No individual was homozygous for the mutant allele and the frequency of the CCR5-Delta32 allele ranged from 0.62% to 3.57%. The CCR5-Delta32 allele frequency was generally lower in populations from southern Pakistan. The overall frequency of the CCR5-Delta32 allele in Pakistan was 2.31%, which is much lower than that found in European populations and similar to that in the Middle East. This is consistent with the historical records and genetic data that indicate a close genetic affinity among these populations. This study demonstrates that the Pakistani population is highly susceptible to M-tropic isolates of HIV-1 and public health measures need to be enforced with urgency if Pakistan is to avoid an HIV epidemic.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Etnicidad
/
Síndrome de Inmunodeficiencia Adquirida
/
VIH-1
/
Eliminación de Secuencia
/
Receptores CCR5
/
Predisposición Genética a la Enfermedad
/
Frecuencia de los Genes
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Asia
/
Europa
Idioma:
En
Revista:
Genet Test
Asunto de la revista:
GENETICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Pakistán
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA