Ultrastructural features of giant cell tumors in Paget's disease.
Clin Orthop Relat Res
; (402): 213-9, 2002 Sep.
Article
en En
| MEDLINE
| ID: mdl-12218487
ABSTRACT
Giant cell tumor is a rare complication of Paget's disease. This association is especially notable in patients originating from Avellino, Italy. Many types of evidence point to a viral etiology for Paget's disease and giant cell tumors arising in it. Three patients who had giant cell tumors and Paget's disease were studied. Two of the patients have a connection to Avellino (one was born in Avellino, and one descended from natives of Avellino). Distinctive light microscopic and ultrastructural features common in these three patients were identified. In all three patients, the giant cell tumors had peculiar irregular aggregates of microfilaments of uncertain genesis. The possibility that these reflect viral infection is discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteítis Deformante
/
Neoplasias Óseas
/
Tumor Óseo de Células Gigantes
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Aged80
/
Humans
/
Male
Idioma:
En
Revista:
Clin Orthop Relat Res
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos