[Effect of a nibentan derivative LKhT53-91 on the heart electrophysiological parameters]. / Vliianie proizvodnogo nibentana LKhT53-91 na élektrofiziologicheskie parametry serdtsa.
Eksp Klin Farmakol
; 65(3): 10-2, 2002.
Article
en Ru
| MEDLINE
| ID: mdl-12227085
ABSTRACT
The compound LKhT5391 (a derivative of nibentan) affects the electrophysiological cardiac parameters to a lower extent than does nibentan. Administered in an effective antiarrhythmogenic dose (comparable with the effective dose of nibentan), LKhT5391 produces a less pronounced and shorter negative chronotropic action than does nibentan. The negative dromotropic effect of the compound studied is manifested only in the atrioventricular node, while not influencing conductivity through the atria and ventricles.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asparagina
/
Benzamidas
/
Corazón
/
Antiarrítmicos
Límite:
Animals
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Asunto de la revista:
FARMACOLOGIA
Año:
2002
Tipo del documento:
Article