Polyploidization and centrosome hyperamplification in inflammatory bronchi.
Inflamm Res
; 51(8): 416-22, 2002 Aug.
Article
en En
| MEDLINE
| ID: mdl-12234059
ABSTRACT
OBJECTIVE AND DESIGN:
Inflammatory and tumorous bronchi were screened in order to obtain new tumor relevant cytogenetic parameters. MATERIAL ORSUBJECTS:
Bronchial cells of 32 patients were cultivated by standard cell culture procedures.METHODS:
Tetraploidy and aneuploidy was determined by enumeration of chromosome 7 and 8 versus the number of centrosomes. The resulting data were correlated with histopathological data.RESULTS:
Tetra- and aneuploidy of epithelial cells were detectable in 76% of tumor cell cultures, 75% of high grade inflammatory tissues and 40% of non- and low grade-inflammatory tissues. Additionally, we observed centrosome hyper-amplification and multipolar mitoses not only in the tumor but also in the early stages of inflammation.CONCLUSION:
Inflammatory bronchi already show tumor-specific features and may consequently represent the preliminary genetic stage of cancer development in bronchi.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Poliploidía
/
Neoplasias de los Bronquios
/
Aberraciones Cromosómicas
/
Centrosoma
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Inflamm Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Alemania