Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus.
Vasa
; 31(3): 191-3, 2002 Aug.
Article
en En
| MEDLINE
| ID: mdl-12236024
ABSTRACT
BACKGROUND:
Ischemic ulcers are usually found above the lateral, and venous stasis ulcers at the medial malleoli. Leg ulcers occur in at least 25% of sickle cell disease (SSD) patients in clinic populations, usually in the malleolar region. The function of the large leg veins in most SSD patients is unimpaired. PATIENTS ANDMETHODS:
We determined leg ulcer location in 41 sickle cell anemia (SS), and 4 sickle-beta 0 thalassemic patients with longstanding chronic and/or recurrent leg ulceration, and reviewed published reports of leg ulcers in hereditary spherocytosis and thalassemias.RESULTS:
Of the 57 legs of the 45 SSD patients with only 1 ulcer, 42 (74%) were medial and 15 lateral. The difference was significant (p < 0.001). Of patients with only a single ulcer, 22 were medial and 4 lateral. Of 15 reported patients with leg ulcers related to spherocytosis or thalassemia, 20/24 (83%) ulcers were medial.CONCLUSIONS:
The medial malleoli are the most common site of leg ulceration in SSD and in other chronic hemolytic anemias. This suggests that stasis may play a role in the leg ulceration associated with chronic hemolytic anemia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Talasemia beta
/
Anemia Hemolítica
/
Anemia de Células Falciformes
/
Úlcera de la Pierna
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Vasa
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos