[Histopathological study of human vas deferens sterilized by intraluminal adhesive agent injection].

PIP: There are more than 300,000 cases of contraception by injection of intraluminal adhesive agent into the vas deferens, and the results have been positive. Many animal experiments have been conducted on the tissue changes in the vas deferens after intraluminal adhesive agent application. This study investigated the morphological change in local tissues of the human vas deferens long after injection of an intraluminal adhesive agent. 11 years after the injection, the adhesive agent still remained in the vas deferens cavity, and was wrapped tightly in febrecyte. It pressed the epithelial tissue of the mucus membrane, which may have caused shedding of the epithelial tissue and the growth of a large quantity of febrecyte in the cavity. Follow-up sections indicated that this epithelial shedding and febrecyte growth may induce tissue stuffing in the vas deferens. Observations showed shortening or disappearance of main cell capillary in the mucus membrane of the vas deferens; it exhibited no distinctive change in cell structure, but did show necrosis of local epithelial cells and colloid tissue insertion. No pathological change in smooth muscle cells was noted, and the vas deferens wall showed no distinctive infiltration of vasitis cells. The study data demonstrate that the remains of the adhesive have no adverse effect upon the vas deferens. The key to success of this method of contraception lies in securing injection of the adhesive into the vas deferens cavity. This is also a major factor in reducing the incidence of vasitis nodes.^ieng